# The AOD-9604 reading list

> Certified Med Spas bibliography — The Certified Med Spas reading list gathers the AOD-9604 publications on fat metabolism, human tolerability, identification and rabbit cartilage.

The original experiments, the human safety summary and the later reviews, gathered by subject.

## Fat metabolism

The [enzyme experiment](https://pubmed.ncbi.nlm.nih.gov/6137122/) and [rat fat-tissue assay](https://pubmed.ncbi.nlm.nih.gov/8358331/) concern C-terminal growth-hormone fragments. The [metabolic characterization of AOD9604](https://pubmed.ncbi.nlm.nih.gov/11146367/), [receptor-knockout experiment](https://pubmed.ncbi.nlm.nih.gov/11713213/) and [fat-oxidation mouse study](https://pubmed.ncbi.nlm.nih.gov/11673763/) extend the biological record. Of these, I’d open the tissue assay first: the distinction between inhibiting fat formation and measuring fat breakdown is unusually clear there.

## Human tolerability

The [human safety report](https://www.jofem.org/index.php/jofem/article/view/157/194) concerns oral AOD9604 in adults with obesity. The [later sports-medicine review](https://pubmed.ncbi.nlm.nih.gov/41966639/) supplies a broader warning about the human safety evidence for unapproved peptides.

## Identity and cartilage

The [seized-preparations case report](https://pubmed.ncbi.nlm.nih.gov/24976118/) and [urine-screening methods paper](https://pubmed.ncbi.nlm.nih.gov/26578461/) address analytical questions. The [rabbit knee study](https://pubmed.ncbi.nlm.nih.gov/26275694/) concerns a different research direction, with a cartilage outcome in an animal model.

## References

[1] Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone https://pubmed.ncbi.nlm.nih.gov/11146367/
[2] Metabolic actions of pituitary growth hormone. I. Inhibition of acetyl CoA carboxylase by human growth hormone and a carboxyl terminal part sequence acting through a second messenger https://pubmed.ncbi.nlm.nih.gov/6137122/
[3] Antilipogenic action of synthetic C-terminal sequence 177-191 of human growth hormone https://pubmed.ncbi.nlm.nih.gov/8358331/
[4] The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice https://pubmed.ncbi.nlm.nih.gov/11713213/
[5] Increase of fat oxidation and weight loss in obese mice caused by chronic treatment with human growth hormone or a modified C-terminal fragment https://pubmed.ncbi.nlm.nih.gov/11673763/
[6] Safety and Tolerability of the Hexadecapeptide AOD9604 in Humans https://www.jofem.org/index.php/jofem/article/view/157/194
[7] Identification and characterization of peptide drugs in unknown pharmaceutical preparations seized by the Belgian authorities: case report on AOD9604 https://pubmed.ncbi.nlm.nih.gov/24976118/
[8] Simplifying and expanding the screening for peptides <2 kDa by direct urine injection, liquid chromatography, and ion mobility mass spectrometry https://pubmed.ncbi.nlm.nih.gov/26578461/
[9] Effect of Intra-articular Injection of AOD9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis Model https://pubmed.ncbi.nlm.nih.gov/26275694/
[10] Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance https://pubmed.ncbi.nlm.nih.gov/41966639/

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I inspect published research at Certified Med Spas; this is an editorial site, not a med-spa business, and nothing here is medical advice.